{"id":8655,"date":"2021-09-30T15:51:15","date_gmt":"2021-09-30T15:51:15","guid":{"rendered":"https:\/\/schmidt-haensch.pwdev.de\/index.php\/2021\/09\/30\/messung-des-cholesteringehalts-fuer-mrna-impfstoffe\/"},"modified":"2024-07-26T07:40:06","modified_gmt":"2024-07-26T07:40:06","slug":"messung-des-cholesteringehalts-fuer-mrna-impfstoffe","status":"publish","type":"post","link":"https:\/\/amazing-pasteur.212-53-165-88.plesk.page\/de\/messung-des-cholesteringehalts-fuer-mrna-impfstoffe\/","title":{"rendered":"Messung des Cholesteringehalts f\u00fcr mRNA-Impfstoffe"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8655\" class=\"elementor elementor-8655 elementor-2600\" 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data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-12f20c19 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12f20c19\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;1467685&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7b8439ad\" data-id=\"7b8439ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-405b697f elementor-widget elementor-widget-text-editor\" data-id=\"405b697f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cholesterin ist eine optisch aktive Substanz mit einer bekannten spezifischen Drehung von -31,6 \u00b0dm-1g-1cm3 in Diethylether [589 nm und 20\u00b0C] [3]. Sie kann in einem Polarimeter gemessen werden, das mit einer Standardwellenl\u00e4nge von 589 nm und einer temperaturgesteuerten R\u00f6hre von 100 mm L\u00e4nge ausgestattet ist. Cholesterin spielt eine wesentliche Rolle in der viralen Replikationsmaschinerie und der Immunaktivierung [1]. Es wird u.a. auch als Teil der Lipid-Adjuvantien von mRNA-Impfstoffen verwendet und erleichtert den Eintritt des Impfstoffs in die menschliche Zelle [2]. Das Varipol B von SCHMIDT + HAENSCH ist das ideale Polarimeter f\u00fcr diese Analyse, die auch von der US Pharmacopeia gefordert wird [4]. Mit der integrierten CRF-21 Part 11 (elektronische Unterschrift) entspricht es auch den aktuellen FDA-Vorschriften.<\/p>\n<p>1. Altan-Bonnet, N., Lipid Tales of Viral Replication and Transmission. Trends Cell Biol, 2017. 27(3): p. 201-213. 2. Reichmuth, A.M., et al., mRNA vaccine delivery using lipid nanoparticles. Ther Deliv, 2016. 7(5): p. 319-34. 3. Landolt, D.H., Rotationskonstanten aktiver K\u00f6rper, in Das optische Drehungsverm\u00f6gen organischer Substanzen. 1879, Friedrich Vieweg und Sohn: Braunschweig. S. 234. 4. Convention, U.S.P., The United States Pharmacopeia, in NF Monographs &#8211; Cholesterol. 2019, THE UNITED STATES PHARMACOPEIALCONVENTION: 12601 Twinbrook Parkway, Rockville, MD 20852.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cholesterin ist eine optisch aktive Substanz mit einer bekannten spezifischen Drehung von -31,6 \u00b0dm-1g-1cm3 in Diethylether [589 nm und 20\u00b0C] [3]. Sie kann in einem Polarimeter gemessen werden, das mit einer Standardwellenl\u00e4nge von 589 nm und einer temperaturgesteuerten R\u00f6hre von 100 mm L\u00e4nge ausgestattet ist. Cholesterin spielt eine wesentliche Rolle in der viralen Replikationsmaschinerie und [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":2601,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"footnotes":"","spc_primary_category":0},"categories":[376,1410],"tags":[391,384,383,385,392],"class_list":["post-8655","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anwendung","category-featured-de","tag-hightech-stoffe","tag-prozessanalytische-systeme","tag-prozesssensorik","tag-qualitatskontrolle-fur-caprolactamherstellung","tag-uberwachung-des-produktionsprozesses"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Messung des Cholesteringehalts f\u00fcr mRNA-Impfstoffe<\/title>\n<meta name=\"description\" content=\"Cholesterin ist eine optisch aktive Substanz mit einer bekannten 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