{"id":18939,"date":"2022-03-14T08:58:35","date_gmt":"2022-03-14T08:58:35","guid":{"rendered":"https:\/\/schmidt-haensch.com\/medicion-del-contenido-de-colesterol-para-vacunas-de-arnm\/"},"modified":"2024-09-09T08:44:24","modified_gmt":"2024-09-09T08:44:24","slug":"medicion-del-contenido-de-colesterol-para-vacunas-de-arnm","status":"publish","type":"post","link":"https:\/\/amazing-pasteur.212-53-165-88.plesk.page\/es\/medicion-del-contenido-de-colesterol-para-vacunas-de-arnm\/","title":{"rendered":"Medici\u00f3n del contenido de colesterol para vacunas de ARNm"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"18939\" class=\"elementor elementor-18939 elementor-2600\" data-elementor-settings=\"{&quot;element_pack_global_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_padding&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true}}\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-12f20c19 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12f20c19\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[{&quot;jet_parallax_layout_image&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;_id&quot;:&quot;1467685&quot;,&quot;jet_parallax_layout_image_tablet&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_image_mobile&quot;:{&quot;url&quot;:&quot;&quot;,&quot;id&quot;:&quot;&quot;,&quot;size&quot;:&quot;&quot;},&quot;jet_parallax_layout_speed&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;jet_parallax_layout_type&quot;:&quot;scroll&quot;,&quot;jet_parallax_layout_direction&quot;:&quot;1&quot;,&quot;jet_parallax_layout_fx_direction&quot;:null,&quot;jet_parallax_layout_z_index&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x&quot;:50,&quot;jet_parallax_layout_bg_x_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_x_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y&quot;:50,&quot;jet_parallax_layout_bg_y_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_y_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size&quot;:&quot;auto&quot;,&quot;jet_parallax_layout_bg_size_tablet&quot;:&quot;&quot;,&quot;jet_parallax_layout_bg_size_mobile&quot;:&quot;&quot;,&quot;jet_parallax_layout_animation_prop&quot;:&quot;transform&quot;,&quot;jet_parallax_layout_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;]}]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7b8439ad\" data-id=\"7b8439ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-405b697f elementor-widget elementor-widget-text-editor\" data-id=\"405b697f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cholesterol plays an essential role in the viral replication machinery and immune activation [1].<\/p>\n<p>It is also used as part of the lipid adjuvants of mRNA vaccines, among others, and facilitates the entry of the vaccine into the human cell [2].<\/p>\n<p>The <a href=\"https:\/\/amazing-pasteur.212-53-165-88.plesk.page\/es\/producto\/serie-varipol\/\">Varipol B<\/a>\u00a0by SCHMIDT + HAENSCH is the ideal polarimeter for this analysis, which is also required by the US Pharmacopeia [4]. With the integrated CRF-21 Part 11 (electronic signature), it also complies with current FDA regulations.<\/p>\n<p>Cholesterol is an optically active substance with a known specific rotation of<\/p>\n<p><strong> -31.6 \u00b0dm<sup>-1<\/sup>g<sup>-1<\/sup>cm<sup>3<\/sup> in diethyl ether [589 nm and 20\u00b0C] [3].<\/strong><\/p>\n<p>It can be measured in a <a href=\"https:\/\/amazing-pasteur.212-53-165-88.plesk.page\/es\/categoria-producto\/instrumentos-de-laboratorio-es\/polarimetro-es\/\">polarimeter<\/a> equipped with a standard wavelength of 589 nm and a temperature-controlled tube of 100\u00a0mm length.<\/p>\n<p>\u00a0<\/p>\n<p>Sources:\u00a0<\/p>\n<p>1. Altan-Bonnet, N., Lipid Tales of Viral Replication and Transmission. Trends Cell Biol, 2017. 27(3): p. 201-213. 2. Reichmuth, A.M., et al., mRNA vaccine delivery using lipid nanoparticles. Ther Deliv, 2016. 7(5): p. 319-34. 3. Landolt, D.H., Rotationsconstanten activer K\u00f6rper, in Das optische Drehungsverm\u00f6gen organischer Substanzen. 1879, Friedrich Vieweg und Sohn: Braunschweig. p. 234. 4. Convention, U.S.P., The United States Pharmacopeia, in NF Monographs \u2013 Cholesterol. 2019, THE UNITED STATES PHARMACOPEIALCONVENTION: 12601 Twinbrook Parkway, Rockville, MD 20852.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cholesterol plays an essential role in the viral replication machinery and immune activation [1]. It is also used as part of the lipid adjuvants of mRNA vaccines, among others, and facilitates the entry of the vaccine into the human cell [2]. The Varipol B\u00a0by SCHMIDT + HAENSCH is the ideal polarimeter for this analysis, which [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":2601,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"footnotes":"","spc_primary_category":0},"categories":[1417,1159],"tags":[1175,1194,1173,1174,1193],"class_list":["post-18939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-es","category-solicitud","tag-control-de-calidad-de-caprolactama","tag-seguimiento-del-proceso-de-produccion","tag-sensor-de-proceso","tag-sistemas-analiticos-de-proceso","tag-tejidos-de-alta-tecnologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Medici\u00f3n del contenido de colesterol para vacunas de ARNm<\/title>\n<meta name=\"description\" content=\"El Varipol B de SCHMIDT + HAENSCH es el polar\u00edmetro ideal para este an\u00e1lisis, que tambi\u00e9n es requerido por la Farmacopea de EE. 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